NOX2/gp91phox Antibody

  • Catalog name: PA1667
  • Supplier name: boster
  • Size: 0,1 mg
  • Price: 320.00€
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  • Target antigen NOX2/gp91phox
  • Clonality Polyclonal antibody
  • Clone Polyclonal antibody
  • Raised in rabbit
  • Type of the antibody IgG polyclonal antibody
  • Product form freeze-dried
  • Reacts with species: human, rat Predicted to work with: mouse
  • Analyses WB,IHC-P
  • Immunogen A synthetic peptide corresponding to a sequence in the middle region of human NOX2(442-459aa YWLCRDTHAFEWFADLLQ), identical to the related rat and mouse sequences.
  • Product configuration Each vial contains 5mg BSA, 0.9mg NaCl, 0.2mg Na2HPO4, 0.05mg Thimerosal, 0.05mg NaN3.
  • Purification Immunogen affinity purified.
  • Solubilization The powdered antibody should be dissolved in 0.2 ml of distilled water to achieve final concentration of 500ug/ml
  • Storage condtions Keep the NOX2/gp91phox Antibodyat minus twenty degrees Celsius for 1 year. The ready-to-use solutions can be stored at four degrees Celsius for a month. Our specialsits recommend to freeze the aliquotes at minus twenty degrees Celsius for long-term application. Multiple procedures of freezing and thawing influence the specifity and reactivity of the antibody in a negative way.
  • Tips The NOX2/gp91phox Antibody did not cross-reacted with other proteins during the test procedures. This antobdy is intended to be used for research analyses and it is not applicale for in vitro diagnostics.
  • Background NOX2(NADPH OXIDASE 2), also called CYBB(CYTOCHROME b(-245), BETA SUBUNIT), p91-PHOX or GP91-1, is a human gene encoding a glycoprotein.NOX2 is an essential component of phagocytic NADPH-oxidase, a membrane-bound enzyme complex that generates large quantities of microbicidal superoxide and other oxidants upon activation. It is mapped on Xp11.4. NOX2 is a heterodimer composed of an alpha chain of relative molecular mass 23 kD and a beta chain of 76 to 82 kD. NOX2 assembled on DC phagosomes in a gp91-phox subunit-dependent manner, and that reactive oxygen species were produced in a more sustained manner in immature DC phagosomes than in macrophage phagosomes. As a major player in innate immune responses in neutrophils, NOX2 is also involved in adaptive immunity through its activity in DCs. In heart cells, physiologic stretch rapidly activates reduced-form NOX2 to produce reactive oxygen species(ROS) in a process dependent on microtubules(X-ROS signaling).
  • Related articles 1. Bionda, C., Li, X. J., van Bruggen, R., Eppink, M., Roos, D., Morel, F., Stasia, M.-J. Functional analysis of two-amino acid substitutions in gp91phox in a patient with X-linked flavocytochrome b(558)-positive chronic granulomatous disease by means of transgenic PLB-985 cells. Hum. Genet. 115: 418-427, 2004. 2. Bolscher, B. G. J. M., de Boer, M., de Klein, A., Weening, R. S., Roos, D. Point mutations in the beta-subunit of cytochrome b(558) leading to X-linked chronic granulomatous disease. Blood 77: 2482-2487, 1991. 3. "Entrez Gene: CYBB cytochrome b-245, beta polypeptide (chronic granulomatous disease)".
  • Gene Name CYBB
  • Protein Name Cytochrome b-245 heavy chain
  • Gene Full Name cytochrome b-245, beta polypeptide
  • Synonyms AMCBX2 antibody|CGD antibody|CGD91-phox antibody|CY24B_HUMAN antibody|CYBB antibody|Cytochrome b 245, beta polypeptide antibody|Cytochrome b(558) beta chain antibody|Cytochrome b(558) subunit beta antibody|Cytochrome b-245 heavy chain antibody|Cytochrome b558 subunit beta antibody|GP91 PHOX antibody|gp91-1 antibody|gp91-phox antibody|GP91PHOX antibody|Heme-binding membrane glycoprotein gp91phox antibody|NADPH oxidase 2 antibody|Neutrophil cytochrome b 91 kDa polypeptide antibody|NOX2 antibody|p22 phagocyte B-cytochrome antibody|P91 PHOX antibody|p91-PHOX antibody|Superoxide-generating NADPH oxidase heavy chain subunit antibody
  • Uniprot ID P04839
  • Properties If you buy Antibodies supplied by boster they should be stored frozen at - 24°C for long term storage and for short term at + 5°C.
  • French translation anticorps