Gene info
TOX Antibody: TOX (thymocyte selection-associated high mobility group (HMG) box protein) is a member of the HMG box family of DNA-binding proteins and likely plays a role in the regulation of T-cell development. It is a 526 amino acid nuclear protein and the expression of TOX is upregulated by pre-T cell receptor (pre-TCR) and TCR activation in immature thymocytes. TOX-mediated positive selection is associated with up-regulation of RUNX3 and is calcineurin dependent. TOX-dependent transition to the CD4+CD8 stage is required for development of class II major histocompatibility complex-specific T cells.
Gene names
TOX Antibody: TOX1, KIAA0808, Thymocyte selection-associated high mobility group box protein TOX, Thymus high mobility group box protein TOX
Antibodie's label
unlabelled serum
Purity
TOX Antibody is affinity chromatography purified via peptide column.
Ab raised in
Rabbit
Type
Polyclonal
Immunoglobulin
IgG
Spicific to
No alternatively spliced transcript variants have been observed.
Antigen
TOX antibody was made against a 17 amino acid synthetic peptide near the amino terminus of human TOX.
Immuno application
ELISA, Western Blot, immuno fluorescence
Antibody advice
TOX antibody can be used for detection of TOX by Western blot at 1 - 2 ug/mL. For immunofluorescence start at 20 ug/mL.
Suspention, pH, azide
TOX Antibody is supplied in PBS containing 0.02% sodium azide.
Keep at
TOX antibody can be stored at 4 grades C for three months and -20 grades C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Works with
Human
Omim nr
7662322
Ncbi nr
NP_055544
KDa
58 kDa
Vial with antibody
in solution
Quantity per ml
1 mg/mL
NCBI GENE nr
9760
GENE symbol
TOX
Antigene name
thymocyte selection-associated high mobility group box protein TOX
Source
homo sapiens
Protein nr
O94900
Properties
If you buy Antibodies supplied by proscience they should be stored frozen at - 24°C for long term storage and for short term at + 5°C.