Gene info
Noxa Antibody: Apoptosis is related to many diseases and development. The p53 tumor-suppressor protein induces apoptosis through transcriptional activation of several genes including p53R2, p53AIP1, and PUMA. A new p53 target gene, Noxa, was recently identified, which encodes a protein belonging to the subfamily of BH3-only proapoptic proteins. Noxa and PUMA are both transcriptional targets of p53 and BH3-only proteins. X-ray irradiation increased p53-dependent Noxa mRNA and protein levels. Noxa, when ectopically expressed, interacted with anti-apoptotic Bcl-2 family members, resulting in the activation of caspase-9. Noxa, like PUMA, localized to mitochondria and induces apoptosis in response to p53. Noxa and PUMA may represent direct mediators of p53-induced apoptosis. Increased levels of p53 and its target gene Noxa was found in the impaired tumor development.
Gene names
Noxa Antibody: Noxa, Phorbol-12-myristate-13-acetate-induced protein 1
Antibodie's label
unlabelled serum
Purity
Noxa Antibody is immunoaffinity chromatography purified IgG.
Ab raised in
Rabbit
Type
Polyclonal
Immunoglobulin
IgG
Antigen
Noxa antibody was made against a synthetic peptide corresponding to 17 amino acids at the amino terminus of mouse Noxa.
Immuno application
ELISA, Western Blot, immuno-histo-chemistry, immuno fluorescence
Antibody advice
Noxa antibody can be used for detection of Noxa by Western blot at at 0.5 - 2 ug/mL. Antibody can also be used for immunohistochemistry starting at 1 ug/mL. For immunofluorescence start at 10 ug/mL.
Suspention, pH, azide
Noxa Antibody is supplied in PBS containing 0.02% sodium azide.
Keep at
Noxa antibody can be stored at 4 grades C for three months and -20 grades C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Works with
Human, Mouse, Rat
Omim nr
10946832
Ncbi nr
NP_067426
Vial with antibody
in solution
Quantity per ml
1 mg/mL
NCBI GENE nr
58801
GENE symbol
Pmaip1
Antigene name
phorbol-12-myristate-13-acetate-induced protein 1
Source
Homo sapiens
Protein nr
Q9JM54
Properties
If you buy Antibodies supplied by proscience they should be stored frozen at - 24°C for long term storage and for short term at + 5°C.