NCF1/p47 phox(Ser359) Antibody, Cy5.5 Conjugated

  • Catalog name: bs-11445R-Cy5.5
  • Supplier name: Bioss Primary Conjugated Antibodies
  • Size: 0.1ml
  • Price: 368.00€
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  • Long name NCF1/p47 phox(Ser359) Antibody, Cy5.5 Conjugated
  • Category Conjugated Primary Antibodies
  • Conjugation Cy5.5
  • Host Organism Rabbit (Oryctolagus cuniculus)
  • Target Antigen NCF1/p47 phox Ser359
  • Specificity This is a highly specific antibody against NCF1/p47 phox Ser359.
  • Modification Phosphorylation
  • Modification site Ser359
  • Clonality Polyclonal
  • Clone Polyclonal antibody
  • Concentration 1ug per 1ul
  • Source KLH conjugated synthetic phosphopeptide derived from human NCF1 around the phosphorylation site of Ser359
  • Gene ID number 653361
  • Tested applications IF(IHC-P)
  • Recommended dilutions IF(IHC-P)(1:50-200)
  • Crossreactivity Human, Rat
  • Crossreactive species details Due to limited amount of testing and knowledge, not every possible cross-reactivity is known.
  • Antigen background The heredity chronic granulomatous disease (CGF) has been linked to mutations in p47-phox and p67-phox. The cytosolic proteins p47-phox and p67-phox, also designated neutrophil cytosol factor (NCF)1 and NCF2, respectively, are required for activation of the superoxide-producing NADPH oxidase in neutrophils and other phagocytic cells. During activation of the NADPH oxidase, p47-phox and p67-phox migrate to the plasma membrane where they associate with cytochrome b558 and the small G protein Rac to form the functional enzyme complex. Both p47-phox and p67-phox contain two Src homology 3 (SH3) domains. The C-terminal SH3 domain of p67-phox has been shown to interact with the proline-rich domain of p47-phox, suggesting that p47-phox may faciliate the transport of p67-phox to the membrane.
  • Purification method This antibody was purified via Protein A.
  • Storage conditions Keep the antibody in an aqueous buffered solution containing 1% BSA, 50% glycerol and 0.09% sodium azide. Store refrigerated at 2 to 8 degrees Celcius for up to 1 year.
  • Excitation Emission 675nm/694nm
  • Synonyms NCF1Ser359; p47 phoxSer359; NCF1 phospho S359; 47 kDa autosomal chronic granulomatous disease protein; 47 kDa neutrophil oxidase factor; NADPH oxidase organizer 2; NCF 47K; Neutrophil cytosol factor 1; Neutrophil cytosolic factor 1; Neutrophil NADPH oxidase factor 1; Nox organizer 2; Nox organizing protein 2; NOXO2; p47 phox; p47phox; ;SH3 and PX domain containing protein 1A; SH3PXD1A; NADPH oxidase p47 phox; NCF1_HUMAN.
  • Properties If you buy Antibodies supplied by Bioss Primary Conjugated Antibodies they should be stored frozen at - 24°C for long term storage and for short term at + 5°C.Cy5 antibodies are excited by the 650-nanometer wave of an argon laser and detected at a 670-nanometer captor.
  • Additional conjugation Cy5.5,Cy5.5
  • Conjugated These antibodies are excite for emission at 678nm and detected at a 694 nm wavelengths.
  • French translation anticorps