Anti-SARM1 (Polyclonal), ALEXA Fluor 594

  • Catalog name: GENTObs-9001R-A594
  • Supplier name: Bioss Polyclonal Antibodies
  • Size: 100 microliters
  • Price: 489.00€
  • Type Conjugated Primary Antibody
  • Conjugated with ALEXA FLUOR® 594
  • Host organism Rabbit (Oryctolagus cuniculus)
  • Target Protein/Peptide SARM1
  • Specificity This antibody reacts specifically with SARM1
  • Modification No modification has been applied to this antibody
  • Modification site None
  • Clonality Polyclonal Antibody
  • Clone Polyclonal Antibodies
  • Concentration 1ug per 1ul
  • Subcellular locations N/A
  • Antigen Source KLH conjugated synthetic peptide derived from human SARM1
  • Gene ID 23098
  • Swiss Prot Q6SZW1
  • Applications IF(IHC-P)
  • Applications with corresponding dilutions IF(IHC-P)(1:50-200)
  • Cross reactive species Human (Homo sapiens), Mouse (Mus musculus), Rat (Rattus norvegicus)
  • Cross Reactive Species details No significant cross reactivity has been observed for this antibody for the tested species. However, note that due to limited knowledge it is impossible to predict with 100% guarantee that the antibody does not corss react with any other species.
  • Background information Negative regulator of MYD88- and TRIF-dependent toll-like receptor signaling pathway which plays a pivotal role in activating axonal degeneration following injury. Promotes Wallerian degeneration an injury-induced axonal death pathway which involves degeneration of an axon distal to the injury site. Can activate neuronal death in response to stress. Regulates dendritic arborization through the MAPK4-JNK pathway. Involved in innate immune response. Inhibits both TICAM1/TRIF- and MYD88-dependent activation of JUN/AP-1, TRIF-dependent activation of NF-kappa-B and IRF3, and the phosphorylation of MAPK14/p38.
  • Purification method Purified by Protein A.
  • Storage Water buffered solution containing 100ug/ml BSA, 50% glycerol and 0.09% sodium azide. Store at 4°C for 12 months.
  • Excitation emission 590nm/617nm
  • Synonyms SARM; SAMD2; MyD88-5; Sterile alpha and TIR motif-containing protein 1; Sterile alpha and Armadillo repeat protein; Sterile alpha motif domain-containing protein 2; SAM domain-containing protein 2; Tir-1 homolog; SARM1; KIAA0524
  • Also known as SARM1 Polyclonal Antibody
  • Other name Anti-SARM1 Polyclonal
  • Advisory Avoid freeze/thaw cycles as they may denaturate the polypeptide chains of the antibody, thus reducing its reactivity, specificity and sensitivity. For antibodies that are in liquid form or reconstituted lyophilized antibodies small amounts could become entrapped on the seal or the walls of the tube. Prior to use briefly centrifuge the vial to gather all the solution on the bottom.
  • Properties For facs or microscopy Alexa 1 conjugate.
  • Conjugation Alexa Fluor,ALEXA FLUOR® 594
  • Conjugated Alexa conjugate 1
  • Group Polyclonals and antibodies
  • About Polyclonals can be used for Western blot, immunohistochemistry on frozen slices or parrafin fixed tissues. The advantage is that there are more epitopes available in a polyclonal antiserum to detect the proteins than in monoclonal sera.