Anti-NCF1/p47 phox(Ser359), ALEXA Fluor 594

  • Catalog name: GENTObs-11445R-A594
  • Supplier name: Bioss Polyclonal Antibodies
  • Size: 100 microliters
  • Price: 516.00€
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  • Type Conjugated Primary Antibody
  • Conjugated with ALEXA FLUOR® 594
  • Host organism Rabbit (Oryctolagus cuniculus)
  • Target Protein/Peptide NCF1/p47 phox Ser359
  • Specificity This antibody reacts specifically with NCF1/p47 phox(Ser359)
  • Modification Phosphorylation
  • Modification site Ser359
  • Clonality Polyclonal Antibody
  • Clone Polyclonal Antibodies
  • Concentration 1ug per 1ul
  • Subcellular locations N/A
  • Antigen Source KLH conjugated synthetic phosphopeptide derived from human NCF1 around the phosphorylation site of Ser359
  • Gene ID 653361
  • Swiss Prot N/A
  • Applications IF(IHC-P)
  • Applications with corresponding dilutions IF(IHC-P)(1:50-200)
  • Cross reactive species Human (Homo sapiens), Rat (Rattus norvegicus)
  • Cross Reactive Species details No significant cross reactivity has been observed for this antibody for the tested species. However, note that due to limited knowledge it is impossible to predict with 100% guarantee that the antibody does not corss react with any other species.
  • Background information The heredity chronic granulomatous disease (CGF) has been linked to mutations in p47-phox and p67-phox. The cytosolic proteins p47-phox and p67-phox, also designated neutrophil cytosol factor (NCF)1 and NCF2, respectively, are required for activation of the superoxide-producing NADPH oxidase in neutrophils and other phagocytic cells. During activation of the NADPH oxidase, p47-phox and p67-phox migrate to the plasma membrane where they associate with cytochrome b558 and the small G protein Rac to form the functional enzyme complex. Both p47-phox and p67-phox contain two Src homology 3 (SH3) domains. The C-terminal SH3 domain of p67-phox has been shown to interact with the proline-rich domain of p47-phox, suggesting that p47-phox may faciliate the transport of p67-phox to the membrane.
  • Purification method Purified by Protein A.
  • Storage Water buffered solution containing 100ug/ml BSA, 50% glycerol and 0.09% sodium azide. Store at 4°C for 12 months.
  • Excitation emission 590nm/617nm
  • Synonyms NCF1Ser359; p47 phoxSer359; NCF1 phospho S359; 47 kDa autosomal chronic granulomatous disease protein; 47 kDa neutrophil oxidase factor; NADPH oxidase organizer 2; NCF 47K; Neutrophil cytosol factor 1; Neutrophil cytosolic factor 1; Neutrophil NADPH oxidase factor 1; Nox organizer 2; Nox organizing protein 2; NOXO2; p47 phox; p47phox; ;SH3 and PX domain containing protein 1A; SH3PXD1A; NADPH oxidase p47 phox; NCF1_HUMAN.
  • Also known as NCF1/p47 phox(Ser359) Antibody
  • Other name Anti-NCF1/p47 phox(Ser359)
  • Advisory Avoid freeze/thaw cycles as they may denaturate the polypeptide chains of the antibody, thus reducing its reactivity, specificity and sensitivity. For antibodies that are in liquid form or reconstituted lyophilized antibodies small amounts could become entrapped on the seal or the walls of the tube. Prior to use briefly centrifuge the vial to gather all the solution on the bottom.
  • Properties For facs or microscopy Alexa 1 conjugate.
  • Conjugation Alexa Fluor,ALEXA FLUOR® 594
  • Conjugated Alexa conjugate 1