Polycystin 2 Antibody, ALEXA FLUOR 555

  • Catalog name: bs-2158R-A555
  • Supplier name: Bioss Primary Conjugated Antibodies. ALEXA FLUOR
  • Size: 100ul
  • Price: 332.75€
  • Long name Polycystin 2 Polyclonal Antibody, ALEXA FLUOR 555 Conjugated
  • Also known as Anti-Polycystin 2 PAb ALEXA FLUOR 555
  • Category Conjugated Primary Antibodies
  • Conjugated with ALEXA FLUOR® 555
  • Host Organism Rabbit (Oryctolagus cuniculus)
  • Target Antigen Polycystin 2
  • Specificity This is a highly specific antibody against Polycystin 2.
  • Modification Unmodified
  • Modification Site None
  • Clonality Polyclonal
  • Clone Polyclonal antibody
  • Concentration 1ug per 1ul
  • Immunogen range 680-720/968
  • Subcellular location Cytoplasm
  • Source This antibody was obtained by immunization of the host with KLH conjugated synthetic peptide derived from human Polycystin 2
  • Gene ID Number 5311
  • Swiss Prot Q13563
  • Tested applications IF(IHC-P)
  • Recommended dilutions IF(IHC-P)(1:50-200)
  • Crossreactivity Human, Mouse, Rat
  • Cross-reactive species details Due to limited amount of testing and knowledge, not every possible cross-reactivity is known.
  • Background of the antigen Functions as a calcium permeable cation channel involved in fluid-flow mechanosensation by the primary cilium in renal epithelium. Together with TRPV4, forms mechano- and thermosensitive channels in cilium (PubMed:18695040). PKD1 and PKD2 may function through a common signaling pathway that is necessary for normal tubulogenesis. Acts as a regulator of cilium length, together with PKD1. The dynamic control of cilium length is essential in the regulation of mechanotransductive signaling. The cilium length response creates a negative feedback loop whereby fluid shear-mediated deflection of the primary cilium, which decreases intracellular cAMP, leads to cilium shortening and thus decreases flow-induced signaling. Also involved in left/right axis specification downstream of nodal flow: forms a complex with PKD1L1 in cilia to facilitate flow detection in left/right patterning (By similarity).
  • Purification Purified by Protein A.
  • Storage conditions Store this antibody in aqueous buffered solution containing 1% BSA, 50% glycerol and 0.09% sodium azide. Keep refrigerated at 2 to 8 degrees Celcius for up to one year.
  • Excitation emission 553nm/568nm
  • Synonyms PC2; PKD4; Pc-2; APKD2; TRPP2; Polycystin-2; Autosomal dominant polycystic kidney disease type II protein; Polycystic kidney disease 2 protein; Polycystwin; R48321; Transient receptor potential cation channel subfamily P member 2; PKD2
  • Properties For facs or microscopy Alexa 1 conjugate.Very high photo stable ALEXA conjugate.If you buy Antibodies supplied by Bioss Primary Conjugated Antibodies. ALEXA FLUOR they should be stored frozen at - 24°C for long term storage and for short term at + 5°C.
  • Conjugation Alexa Fluor,ALEXA FLUOR 555
  • French translation anticorps