BIG1/ARFGEF1 Antibody, ALEXA FLUOR 594

  • Catalog name: bs-12866R-A594
  • Supplier name: Bioss Primary Conjugated Antibodies. ALEXA FLUOR
  • Size: 100ul
  • Price: 332.75€
  • Long name BIG1/ARFGEF1 Polyclonal Antibody, ALEXA FLUOR 594 Conjugated
  • Also known as Anti-BIG1/ARFGEF1 PAb ALEXA FLUOR 594
  • Category Conjugated Primary Antibodies
  • Conjugated with ALEXA FLUOR® 594
  • Host Organism Rabbit (Oryctolagus cuniculus)
  • Target Antigen BIG1/ARFGEF1
  • Specificity This is a highly specific antibody against BIG1/ARFGEF1.
  • Modification Unmodified
  • Modification Site None
  • Clonality Polyclonal
  • Clone Polyclonal antibody
  • Concentration 1ug per 1ul
  • Source This antibody was obtained by immunization of the host with KLH conjugated synthetic peptide derived from human BIG1/ARFGEF1
  • Gene ID Number 10565
  • Tested applications IF(IHC-P)
  • Recommended dilutions IF(IHC-P)(1:50-200)
  • Crossreactivity Human, Mouse, Rat
  • Cross-reactive species details Due to limited amount of testing and knowledge, not every possible cross-reactivity is known.
  • Background of the antigen Guanine nucleotide-exchange proteins (GEPs) accelerate replacement of bound GDP with GTP and thereby activate ADP-ribosylation factors (ARFs), a family of guanine nucleotide-binding proteins that play an important role in intracellular vesicular trafficking. GEPs comprise two major families, large GEPs that are inhibited by brefeldin A (BFA), a protein that effects Golgi structure and a group of smaller GEPs that are insenstive to BFA. Two genes for GEPs found on human chromosomes 8 and 20 encode BFA sensitive GEPs designated BIG1 and BIG2. Both GEPS contain a sec7 domain that is responsible for their brefeldin inhibition and also their catalytic activity. In vivo, BIG1 and BIG2 exist in macromolecular complexes that move between the Golgi membranes and cytosol. BIG2 associates with PKA regulatory subunits, implying that BIG2 may act as an A kinase-anchoring protein (AKAP) that could coordinate the cAMP and ARF regulatory pathways.
  • Purification Purified by Protein A.
  • Storage conditions Store this antibody in aqueous buffered solution containing 1% BSA, 50% glycerol and 0.09% sodium azide. Keep refrigerated at 2 to 8 degrees Celcius for up to one year.
  • Excitation emission 590nm/617nm
  • Synonyms ADPribosylation factor guanine nucleotide exchange factor 1brefeldin A inhibited; ARFGEF1; ARFGEP1; Brefeldin A inhibited GEP 1; Brefeldin A inhibited guanine nucleotide exchange protein 1; p200 ARF GEP1; p200 ARF guanine nucleotide exchange factor; BIG1_HUMAN.
  • Properties For facs or microscopy Alexa 1 conjugate.If you buy Antibodies supplied by Bioss Primary Conjugated Antibodies. ALEXA FLUOR they should be stored frozen at - 24°C for long term storage and for short term at + 5°C.
  • Conjugation Alexa Fluor,ALEXA FLUOR® 594
  • Conjugated Alexa conjugate 1
  • French translation anticorps