Ack1 (Tyr284) Antibody, ALEXA FLUOR 555

  • Catalog name: bs-3045R-A555
  • Supplier name: Bioss Primary Conjugated Antibodies. ALEXA FLUOR
  • Size: 100ul
  • Price: 350.15€
  • Long name Ack1 (Tyr284) Polyclonal Antibody, ALEXA FLUOR 555 Conjugated
  • Also known as Anti-Ack1 Tyr284 PAb ALEXA FLUOR 555
  • Category Conjugated Primary Antibodies
  • Conjugated with ALEXA FLUOR® 555
  • Host Organism Rabbit (Oryctolagus cuniculus)
  • Target Antigen Ack1 Tyr284
  • Specificity This is a highly specific antibody against Ack1 Tyr284.
  • Modification Phosphorylation
  • Modification Site Tyr284
  • Clonality Polyclonal
  • Clone Polyclonal antibody
  • Concentration 1ug per 1ul
  • Immunogen range 260-310/1055
  • Subcellular location Nucleus, Membrane bound
  • Source KLH conjugated synthetic phosphopeptide derived from mouse Ack1 around the phosphorylation site of Tyr284
  • Gene ID Number 51789
  • Swiss Prot O54967
  • Tested applications FCM, IF(IHC-P)
  • Recommended dilutions FCM(1:20-100), IF(IHC-P)(1:50-200)
  • Crossreactivity Human, Mouse, Rat
  • Cross-reactive species details Due to limited amount of testing and knowledge, not every possible cross-reactivity is known.
  • Background of the antigen Non-receptor tyrosine-protein and serine/threonine-protein kinase that is implicated in cell spreading and migration, cell survival, cell growth and proliferation. Transduces extracellular signals to cytosolic and nuclear effectors. Phosphorylates AKT1, AR, MCF2, WASL and WWOX. Implicated in trafficking and clathrin-mediated endocytosis through binding to epidermal growth factor receptor (EGFR) and clathrin. Binds to both poly- and mono-ubiquitin and regulates ligand-induced degradation of EGFR, thereby contributing to the accumulation of EGFR at the limiting membrane of early endosomes. Downstream effector of CDC42 which mediates CDC42-dependent cell migration via phosphorylation of BCAR1. May be involved both in adult synaptic function and plasticity and in brain development. Activates AKT1 by phosphorylating it on 'Tyr-176'. Phosphorylates AR on 'Tyr-267' and 'Tyr-363' thereby promoting its recruitment to androgen-responsive enhancers (AREs). Phosphorylates WWOX on 'Tyr-287'. Phosphorylates MCF2, thereby enhancing its activity as a guanine nucleotide exchange factor (GEF) toward Rho family proteins. Contributes to the control of AXL receptor levels. Confers metastatic properties on cancer cells and promotes tumor growth by negatively regulating tumor suppressor such as WWOX and positively regulating pro-survival factors such as AKT1 and AR.
  • Purification Purified by Protein A.
  • Storage conditions Store this antibody in aqueous buffered solution containing 1% BSA, 50% glycerol and 0.09% sodium azide. Keep refrigerated at 2 to 8 degrees Celcius for up to one year.
  • Excitation emission 553nm/568nm
  • Synonyms Ack; Ack1; Pyk1; Ack-1; Cdgip; Activated CDC42 kinase 1; Non-receptor protein tyrosine kinase Ack; Tyrosine kinase non-receptor protein 2; Tnk2
  • Properties For facs or microscopy Alexa 1 conjugate.Very high photo stable ALEXA conjugate.If you buy Antibodies supplied by Bioss Primary Conjugated Antibodies. ALEXA FLUOR they should be stored frozen at - 24°C for long term storage and for short term at + 5°C.
  • Conjugation Alexa Fluor,ALEXA FLUOR 555
  • French translation anticorps