ZWILCH Antibody

  • Catalog name: bs-9732R
  • Supplier name: Bioss Primary Unconjugated Antibodies
  • Size: 0.1ml
  • Price: 263.00€
  • Long name ZWILCH Primary Polyclonal Antibody
  • Also known as ZWILCH PAb
  • Category Primary Antibodies
  • Conjugation Unconjugated
  • Target Antigen ZWILCH
  • Specificity This is a highly specific antibody against ZWILCH.
  • Modification(s) None
  • Modification site(s) Unmodified antibody
  • Clonality Polyclonal antibody
  • Clone number Polyclonal antibody
  • Concentration 1ug per 1ul
  • Source This antibody was obtained by immunization of the host with KLH conjugated synthetic peptide derived from human ZWILCH
  • Gene ID number 55055
  • Tested Applications WB, IHC-P, IF(IHC-P)
  • Recommended dilutions WB(1:100-1000), IHC-P(1:100-500), IF(IHC-P)(1:50-200)
  • Cross reactivity Human, Mouse, Rat
  • Cross reactive species details Due to limited amount of testing and knowledge, not every possible cross-reactivity is known.
  • Background of the target antigen Zwilch is the human homolog of the Drosophila Zwilch protein. The Drosophila Zwilch forms a complex with both ROD Rough Deal) and ZWINT (Zeste-White 10, also designated ZW10) proteins. This complex is important for chromosome segregation because it recruits cytoplasmic Dynein to the kinetochore and plays a crucial role in the spindle checkpoint. The role of Zwilch in complex is thought to be evolutionarily conserved because the human homologs of Zwilch, ZWINT and ROD coimmunoprecipitate in a human cell line called HeLa. The human Zwilch, ZWINT and ROD complex localizes to the kinetochores at prometaphase. Mutations were discovered in Zwilch, ZWINT and ROD during a screen for mutations in alleles encoding putative chromosome instability genes in cases of human colorectal cancer. These mutations may contribute in part to the chromosomal instability phenotype of colorectal tumor cells.
  • Purification method This antibody was purified via Protein A.
  • Storage conditions Keep the antibody in aqueous buffered solution containing 1% BSA, 50% glycerol and 0.09% sodium azide. Store at -20°C for up to 1 year.
  • Synonym names hZwilch; KNTC1AP; MGC111034; Protein zwilch homolog; ZWILC_HUMAN; zwilch;y ZWILCH protein; Zwilch, kinetochore associated, homolog.
  • Properties If you buy Antibodies supplied by Bioss Primary Unconjugated Antibodies they should be stored frozen at - 24°C for long term storage and for short term at + 5°C.
  • French translation anticorps