C-rel (318CT41.3.2) Monoclonal Antibody

  • Catalog name: bsm-51087M
  • Supplier name: Bioss Primary Unconjugated Antibodies
  • Size: 0.1ml
  • Price: 328.00€
  • Long name C-rel (318CT41.3.2) Monoclonal Antibody
  • Also known as C-rel (318CT41.3.2) Monoclonal Antibody
  • Category Primary Antibodies
  • Conjugation Unconjugated
  • Target Antigen C-rel
  • Specificity This is a highly specific antibody against C-rel.
  • Modification(s) None
  • Modification site(s) Unmodified antibody
  • Clonality Monoclonal
  • Clone number 318CT41.3.2
  • Source This REL monoclonal antibody is generated from mouse immunized with REL recombinant protein.
  • Gene ID number 5966
  • Swiss Prot Q04864
  • Tested Applications WB, IF
  • Recommended dilutions WB(1:500~16000) , IF(1:10~50),
  • Cross reactivity Human
  • Cross reactive species details Due to limited amount of testing and knowledge, not every possible cross-reactivity is known.
  • Background of the target antigen Proto-oncogene that may play a role in differentiation and lymphopoiesis. NF-kappa-B is a pleiotropic transcription factor which is present in almost all cell types and is involved in many biological processed such as inflammation, immunity, differentiation, cell growth, tumorigenesis and apoptosis. NF-kappa-B is a homo- or heterodimeric complex formed by the Rel-like domain-containing proteins RELA/p65, RELB, NFKB1/p105, NFKB1/p50, REL and NFKB2/p52. The dimers bind at kappa-B sites in the DNA of their target genes and the individual dimers have distinct preferences for different kappa-B sites that they can bind with distinguishable affinity and specificity. Different dimer combinations act as transcriptional activators or repressors, respectively. NF-kappa-B is controlled by various mechanisms of post-translational modification and subcellular compartmentalization as well as by interactions with other cofactors or corepressors. NF-kappa-B complexes are held in the cytoplasm in an inactive state complexed with members of the NF-kappa-B inhibitor (I-kappa-B) family. In a conventional activation pathway, I-kappa-B is phosphorylated by I-kappa-B kinases (IKKs) in response to different activators, subsequently degraded thus liberating the active NF-kappa-B complex which translocates to the nucleus. The NF-kappa-B heterodimer RELA/p65-c-Rel is a transcriptional activator.
  • Purification method Mouse monoclonal antibody supplied in crude ascites with 0.09% (W/V) sodium azide.
  • Storage conditions Keep the antibody in aqueous buffered solution containing 1% BSA, 50% glycerol and 0.09% sodium azide. Store at -20°C for up to 1 year.
  • Synonym names C-Rel; Proto-oncogene c-Rel; REL
  • Properties If you buy Antibodies supplied by Bioss Primary Unconjugated Antibodies they should be stored frozen at - 24°C for long term storage and for short term at + 5°C.
  • About Monoclonals of this antigen are available in different clones. Each murine monoclonal anibody has his own affinity specific for the clone. Mouse monoclonal antibodies are purified protein A or G and can be conjugated to FITC for flow cytometry or FACS and can be of different isotypes.
  • French translation anticorps