SIX2 Antibody

  • Catalog name: bs-12365R
  • Supplier name: Bioss Primary Unconjugated Antibodies
  • Size: 0.1ml
  • Price: 263.00€
  • Long name SIX2 Primary Polyclonal Antibody
  • Also known as SIX2 PAb
  • Category Primary Antibodies
  • Conjugation Unconjugated
  • Target Antigen SIX2
  • Specificity This is a highly specific antibody against SIX2.
  • Modification(s) None
  • Modification site(s) Unmodified antibody
  • Clonality Polyclonal antibody
  • Clone number Polyclonal antibody
  • Concentration 1ug per 1ul
  • Source This antibody was obtained by immunization of the host with KLH conjugated synthetic peptide derived from human SIX2
  • Gene ID number 10736
  • Tested Applications WB, IHC-P, IF(IHC-P)
  • Recommended dilutions WB(1:100-1000), IHC-P(1:100-500), IF(IHC-P)(1:50-200)
  • Cross reactivity Human, Mouse, Rat
  • Cross reactive species details Due to limited amount of testing and knowledge, not every possible cross-reactivity is known.
  • Background of the target antigen The Six proteins (sine oculis) are a family of homeodomain transcription factors that share a conserved DNA binding domain. Six2, Six4 (AREC3) and Six5 bind to the same DNA sequence, indicating that they may regulate the same target genes. Six1 and Six4 are both capable of transactivating MEF3 site containing reporter genes, such as myogenin. It has been demonstrated that alterations to homeobox-containing genes may result in cancer. Six1 expression has been shown to be absent or low in normal adult tissues, although it is expressed in several tumor types, including breast carcinoma. Six1 overexpression has been shown to abrogate the G2 cell cycle checkpoint. Six2 is highly expressed in fetal tissues but expression is limited in adult tissues.
  • Purification method This antibody was purified via Protein A.
  • Storage conditions Keep the antibody in aqueous buffered solution containing 1% BSA, 50% glycerol and 0.09% sodium azide. Store at -20°C for up to 1 year.
  • Synonym names Homeobox protein SIX2; OTTHUMP00000201649; Sine oculis homeobox Drosophila homolog 2; Sine oculis homeobox homolog 2; Sine oculis homeobox homolog 2 Drosophila; SIX homeobox 2; Six2; SIX2_HUMAN.
  • Properties If you buy Antibodies supplied by Bioss Primary Unconjugated Antibodies they should be stored frozen at - 24°C for long term storage and for short term at + 5°C.
  • French translation anticorps