Long description This peptide is the immunogen used to make Cat # X2764P. _x000B__x000B_Protects against mitochondrial dysfunction during cellular stress, potentially by phosphorylating mitochondrial proteins. Involved in the clearance of damaged mitochondria via selective autophagy (mitophagy). It is necessary for PARK2 recruitment to dysfunctional mitochondria to initiate their degradation. Defects in PINK1 are the cause of Parkinson disease type 6 (PARK6). A neurodegenerative disorder characterized by parkinsonian signs such as rigidity, resting tremor and bradykinesia. A subset of patients manifest additional symptoms including hyperreflexia, autonomic instability, dementia and psychiatric disturbances. Symptoms show diurnal fluctuation and can improve after sleep.
Antibody come from Synthetic peptide corresponding to amino acids 246-265 derived from the carboxyl terminal of the canine SRbeta subunit.
Other description Provided as solution in phosphate buffered saline with 0.08% sodium azide.
Antibody's reacts with Blocking Peptide to Cat # X2764P
Antibody's reacts with these species This antibody doesn't cross react with other species
Antibody's specificity No Data Available
Application Blocking Peptide
Antibody's suited for Detects SRbeta by Western blot analysis at 15 µg/ml. Antibody will not detect SRbeta protein bound to SRalpha. Optimal concentration should be evaluated by serial dilutions.
Relevant references 1. Bacher, G., et al. The ribosome regulates the GTPase of the beta-subunit of the signal recognition particle receptor. J. Cell. Biol. 1999, 146, 723-730._x000B__x000B_2. Ogg SC, et al. A functional GTPase domain, but not its transmembrane domain, is required for function of the SRP receptor beta-subunit. J. Cell. Biol. 1998, 142, 341-354._x000B__x000B_3. Young, J.C., et al. An amino-terminal domain containing hydrophobic and hydrophilic sequences binds the signal recognition particle receptor alpha subunit to the beta subunit on the endoplasmic reticulum membrane. J. Biol. Chem. 1995, 270, 15650-15657._x000B_
Protein number see ncbi
Warnings This product is intended FOR RESEARCH USE ONLY, and FOR TESTS IN VITRO, not for use in diagnostic or therapeutic procedures involving humans or animals. This datasheet is as accurate as reasonably achievable, but Nordic-MUbio accepts no liability for any inaccuracies or omissions in this information.
Test You can block the antibody by the specific target amino acid sequence of peptide.