Long description This peptide is the immunogen used to make Cat # X2757P. _x000B__x000B_The function of this binding protein is not fully known. It is known to interact with the S100P and colocalizes with S100P in the nucleus. S100P may stimulate cell proliferation in an autocrine manner via activation of the receptor for activated glycation end products (RAGE). Expressed in brain, spleen, and lung. Not detected in pancreas or liver. In pancreas, expressed predominantly in islet cells and to a lesser extent in acinar cells, but not expressed in ductal cells. Up-regulated in various pancreatic ductal adenocarcinomas and pancreatic intraepithelial neoplasias. Detected in pancreatic ductal adenocarcinoma cells (at protein level). Not detected in non-neoplastic ductal epithelium (at protein level).
Antibody come from Synthetic peptide derived from the human PD1 protein.
Other description Provided as solution in phosphate buffered saline with 0.08% sodium azide.
Clone not specified
Antigen-antibody binding interaction S100P-Binding Protein - Blocking Peptide
Antibody is raised in see techfile
Antibody's reacts with Blocking Peptide to Cat # X2757P
Antibody's reacts with these species This antibody doesn't cross react with other species
Antibody's specificity No Data Available
Application Blocking Peptide
Antibody's suited for Antibody can be used for immunohistochemistry (2-4 µg/ml) and Western blotting (1-2 µg/ml). Optimal concentration should be evaluated by serial dilutions.
Relevant references 1. Shinohara, T., et al. ÔStructure and chromosomal localization of the human PD-1 gene (PDCD1)Ó Genomics, 23, 704-706 (1994)_x000B_2. Fife, B.T., Pauken, K.E. ÔThe role of the PD-1 pathway in autoimmunity and peripheral tolerance.Ó Ann. N.Y. Acad. Sci., 1217, 45-59 (2011)_x000B_
Protein number see ncbi
Warnings This product is intended FOR RESEARCH USE ONLY, and FOR TESTS IN VITRO, not for use in diagnostic or therapeutic procedures involving humans or animals. This datasheet is as accurate as reasonably achievable, but Nordic-MUbio accepts no liability for any inaccuracies or omissions in this information.
Test You can block the antibody by the specific target amino acid sequence of peptide.