Long description This peptide is the immunogen used to make Cat # X2756P. _x000B__x000B_Required for formation of the RNA induced silencing complex (RISC). Component of the RISC loading complex (RLC), also known as the micro-RNA (miRNA) loading complex (miRLC), which is composed of DICER1, EIF2C2/AGO2 and TARBP2. Within the RLC/miRLC, DICER1 and TARBP2 are required to process precursor miRNAs (pre-miRNAs) to mature miRNAs and then load them onto EIF2C2/AGO2. EIF2C2/AGO2 bound to the mature miRNA constitutes the minimal RISC and may subsequently dissociate from DICER1 and TARBP2. Also cleaves double-stranded RNA to produce short interfering RNAs (siRNAs) which target the selective destruction of complementary RNAs.
Antibody come from Synthetic peptide derived from the human SALL4 protein
Other description Provided as solution in phosphate buffered saline with 0.08% sodium azide.
Antibody's reacts with Blocking Peptide to Cat # X2756P
Antibody's reacts with these species This antibody doesn't cross react with other species
Antibody's specificity No Data Available
Application Blocking Peptide
Antibody's suited for Antibody can be used for Immunohistochemistry (2-4 µg/ml) and Western blotting (1-2 µg/ml). Optimal concentration should be evaluated by serial dilutions.
Relevant references 1. Ma, Y., et al. ÔSALL4, a novel oncogene, is constitutively expressed in human acute myeloid leukemia (AML) and induces AML in transgenic mice.Õ Blood, 108, 2726-2735 (2006)_x000B_2. Kohlhase, J., et al. ÔOkihiro syndrome is caused by SALL4 mutations.Õ Hum. Mol. Genet., 11, 2979-2987 (2002)_x000B_3. Yang, F., et al. ÔSumoylation is important for stability, subcellular localization, and transcriptional activity of SALL4, an essential stem cell transcription factor.Õ J. Biol. Chem., 287, 38600-38608 (2012)
Protein number see ncbi
Warnings This product is intended FOR RESEARCH USE ONLY, and FOR TESTS IN VITRO, not for use in diagnostic or therapeutic procedures involving humans or animals. This datasheet is as accurate as reasonably achievable, but Nordic-MUbio accepts no liability for any inaccuracies or omissions in this information.
Test You can block the antibody by the specific target amino acid sequence of peptide.