Long description This peptide is the immunogen used to make Cat # X2753P. _x000B__x000B_Variant histone H2A which replaces conventional H2A in a subset of nucleosomes. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. Required for checkpoint-mediated arrest of cell cycle progression in response to low doses of ionizing radiation and for efficient repair of DNA double strand breaks (DSBs) specifically when modified by C-terminal phosphorylation.
Antibody come from Synthetic peptide derived from human HSF1 protein.
Other description Provided as solution in phosphate buffered saline with 0.08% sodium azide.
Antibody's reacts with Blocking Peptide to Cat # X2753P
Antibody's reacts with these species This antibody doesn't cross react with other species
Antibody's specificity No Data Available
Application Blocking Peptide
Antibody's suited for Antibody can be used for immunohistochemistry (2 µg/ml) and Western blotting (1-2 µg/ml). Optimal concentration should be evaluated by serial dilutions.
Relevant references 1. Jin, X., et al. ÔTargeted deletion of Hsf1, 2, and 4 genes in mice.Õ Methods Mol. Biol., 787, 1-20 (2011)_x000B_2. Kaitsuka, T., et al. ÔTransformation of eEF1Bdelta into heat-shock response transcription factor by alternative splicing.Õ EMBO Rep., 12, 673-681 (2011)_x000B_
Protein number see ncbi
Warnings This product is intended FOR RESEARCH USE ONLY, and FOR TESTS IN VITRO, not for use in diagnostic or therapeutic procedures involving humans or animals. This datasheet is as accurate as reasonably achievable, but Nordic-MUbio accepts no liability for any inaccuracies or omissions in this information.
Test You can block the antibody by the specific target amino acid sequence of peptide.