Rabbit anti 5T4 Oncofetal Trophoblast glycoprotein
Catalog name: X2738P
Supplier name: nordc
Size: 100 μg
Category Primary Antibodies
Long description 5T4 is a N-glycosylated transmembrane 72 kDa (420 AA) glycoprotein containing seven leucine-rich repeat regions. 5T4 is often referred to as an oncofetal antigen due to its expression in fetal trophoblast where it was first discovered or trophoblast glycoprotein (TPBG). 5T4 oncofetal antigen is defined by a monoclonal antibody originally raised against human placental trophoblast and which recognizes a 72 kD glycoprotein expressed in a variety of different carcinomas but detected only at very low levels in normal epithelia. Patterns of expression of 5T4 oncofetal antigen in colorectal carcinomas indicate a significant association with tumor metastasis. By IHC, 71% of the carcinomas demonstrate positive 5T4 immunoreactivity in adenocarcinoma cells and/or associated stromal tissue.5T4 is found in tumors including the colorectal, ovarian, and gastric. Its expression is used as a prognostic aid in these cases. 5T4 is widespread in malignant tumors throughout the various stages of their development._x000B__x000B_In assessing the 5T4 phenotype it has been determined that there is a significant correlation between 5T4 expression and advanced stage of disease (FIGO stages III and IV) (P <0.001) and with poorly differentiated tumors (P = 0.036) compared to well or moderately differentiated tumors. Patients with tumors expressing 5T4 were are likely to respond well to adjuvant therapy and have a significantly worse outlook in terms of survival and disease-free interval.
Antibody come from Synthetic peptide derived from human S100P-binding protein.
Other description Provided as solution in phosphate buffered saline with 0.08% sodium azide. Antigen Immunoaffinity Purification
Antigen-antibody binding interaction Rabbit anti 5T4 Oncofetal Trophoblast glycoprotein Antibody
Antibody is raised in Rabbit
Antibody's reacts with Human
Antibody's reacts with these species This antibody doesn't cross react with other species
Antibody's specificity No Data Available
Application Immunohistochemistry, Western Blot, ELISA
Antibody's suited for Optimal concentration should be evaluated by serial dilutions.
Relevant references 1. Dowen, S.E., et al. ÔExpression of S100P and its novel binding partner S100PBPR in early pancreatic cancer.Õ Am. J. Pathol., 166, 81-92 (2005)_x000B__x000B_2. Deng, H., et al. ÔUsefulness of S100P in diagnosis of adenocarcinoma of pancreas on fine-needle aspiration biopsy specimens.Õ Am. J. Clin. Pathol., 129, 81-88 (2008)
Protein number see ncbi
Warnings This product is intended FOR RESEARCH USE ONLY, and FOR TESTS IN VITRO, not for use in diagnostic or therapeutic procedures involving humans or animals. This datasheet is as accurate as reasonably achievable, but Nordic-MUbio accepts no liability for any inaccuracies or omissions in this information.
About Rabbits are used for polyclonal antibody production by nordc. Rabbit antibodies are very stable and can be stored for several days at room temperature. nordc adds sodium azide and glycerol to enhance the stability of the rabbit polyclonal antibodies. Anti-human, anti mouse antibodies to highly immunogenic selected peptide sequences are" monoclonal like" since the epitope to which they are directed is less than 35 amino acids long.