Rabbit anti Calcium Homeostasis Modulator Protein 1
Catalog name: X2723P
Supplier name: nordc
Category Primary Antibodies
Long description CALHM1 controls cytosolic Ca2+ permeability and cytosolic Ca2+ concentration. It controls amyloid precursor protein (APP) proteolysis and aggregated amyloid-beta (Abeta) peptides levels in a Ca2+ dependent manner. However, no association between CALHM1 and AlzheimerÕs risk is unclear. Member of the FAM26 family of proteins. CALHM1 is predominantly expressed in the adult brain. It has also been detected in retinoic acid-differentiated SH-SY5Y cells. Also colocalizes with HSPA5 at the endoplasmic reticulum.
Antibody come from Synthetic Peptide near C terminal of human Sirt 1
Other description Provided as solution in phosphate buffered saline with 0.08% sodium azide. Ammonium Sulfate Precipitation
Antigen-antibody binding interaction Rabbit anti Calcium Homeostasis Modulator Protein 1 Antibody
Antibody is raised in Rabbit
Antibody's reacts with Human
Antibody's reacts with these species This antibody doesn't cross react with other species
Antibody's specificity No Data Available
Application Western Blotting, ELISA
Antibody's suited for Optimal concentration should be evaluated by serial dilutions.
Relevant references 1. SIRT1 induces EMT by cooperating with EMT transcription factors and enhances prostate cancer cell migration and metastasis. Byles V, Zhu L, Lovaas JD, Chmilewski LK, Wang J, Faller DV, Dai Y. Oncogene. 2012 Jan 16. doi: 10.1038/onc.2011.612. _x000B__x000B_2. SIRT1 activates MAO-A in the brain to mediate anxiety and exploratory drive. Libert S, Pointer K, Bell EL, Das A, Cohen DE, Asara JM, Kapur K, Bergmann S, Preisig M, Otowa T, Kendler KS, Chen X, Hettema JM, van den Oord EJ, Rubio JP, Guarente L. Cell. 2011 Dec 23;147(7):1459-72. Epub 2011 Dec 8._x000B__x000B_3. Role of SIRT1 in heat stress- and lipopolysaccharide-induced immune and defense gene expression in human dental pulp cells. Lee SI, Min KS, Bae WJ, Lee YM, Lee SY, Lee ES, Kim EC. J Endod. 2011 Nov;37(11):1525-30. Epub 2011 Sep 9._x000B__x000B_4. p53 deacetylation by SIRT1 decreases during protein kinase CKII downregulation-mediated cellular senescence. Jang SY, Kim SY, Bae YS. FEBS Lett. 2011 Nov 4;585(21):3360-6. Epub 2011 Sep 29._x000B__x000B_5. SIRT1 deacetylates the DNA methyltransferase 1 (DNMT1) protein and alters its activities. Peng L, Yuan Z, Ling H, Fukasawa K, Robertson K, Olashaw N, Koomen J, Chen J, Lane WS, Seto E. Mol Cell Biol. 2011 Dec;31(23):4720-34. Epub 2011 Sep 26_x000B__x000B_6. SIRT1 is essential for oncogenic signaling by estrogen/estrogen receptor in breast cancer. Elangovan S, Ramachandran S, Venkatesan N, Ananth S, Gnana-Prakasam JP, Martin PM, Browning DD, Schoenlein PV, Prasad PD, Ganapathy V, Thangaraju M. Cancer Res. 2011 Nov 1;71(21):6654-64. Epub 2011 Sep 15._x000B__x000B_7. Roles of SIRT1 in high glucose-induced endothelial impairment: association with diabetic atherosclerosis. Yang J, Wang N, Zhu Y, Feng P. Arch Med Res. 2011 Jul;42(5):354-60. doi: 10.1016/j.arcmed.2011.07.005. Epub 2011 Jul 31._x000B__x000B_8. Sirt1 deacetylates c-Myc and promotes c-Myc/Max association. Mao B, Zhao G, Lv X, Chen HZ, Xue Z, Yang B, Liu DP, Liang CC. Int J Biochem Cell Biol. 2011 Nov;43(11):1573-81. Epub 2011 Jul 22.
Protein number see ncbi
Warnings This product is intended FOR RESEARCH USE ONLY, and FOR TESTS IN VITRO, not for use in diagnostic or therapeutic procedures involving humans or animals. This datasheet is as accurate as reasonably achievable, but Nordic-MUbio accepts no liability for any inaccuracies or omissions in this information.
About Rabbits are used for polyclonal antibody production by nordc. Rabbit antibodies are very stable and can be stored for several days at room temperature. nordc adds sodium azide and glycerol to enhance the stability of the rabbit polyclonal antibodies. Anti-human, anti mouse antibodies to highly immunogenic selected peptide sequences are" monoclonal like" since the epitope to which they are directed is less than 35 amino acids long.