Rabbit anti Voltage-dependent T-type calcium channel subunit alpha-1I
Catalog name: X2716P
Supplier name: nordc
Category Primary Antibodies
Long description Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death. T-type channels serve pacemaking functions in both central neurons and cardiac nodal cells and support calcium signaling in secretory cells and vascular smooth muscle. They may also be involved in the modulation of firing patterns of neurons which is important for information processing as well as in cell growth processes. Using co-transfection techniques we investigated the functional effects of each of the gamma subunits on the biophysics of the T-type VSCC encoded by the alpha(1I) subunit. This revealed a substantially slowed rate of deactivation in the presence of gamma(2). In contrast, there was no significant corresponding effect of either gamma(3) or gamma(4) on alpha(1I) subunit-mediated currents.(2)
Antibody come from Synthetic peptide derived from the human LRRK2 protein
Other description Provided as solution in phosphate buffered saline with 0.08% sodium azide. Antigen Immunoaffiinity Purification
Antibody's reacts with these species This antibody doesn't cross react with other species
Antibody's specificity No Data Available
Application Western Blot
Antibody's suited for Antibody can be used for immunohistochemistry (5-10 µg/ml). Optimal concentration should be evaluated by serial dilutions.
Relevant references 1. Glasson, B.I., et al. 'Biochemical and pathological characterization of Lrrk2.' Ann Neurol. 2006, 59, 315-322_x000B__x000B_2. Miklossy, J., et al. 'LRRK2 expression in normal and pathologic human brain and in human cell lines.' J. Neuropathol Exp. Neurol. 2006, 65, 953-963_x000B__x000B_3. Alegre-Abarrategui, J., et al. 'LRRK2 is a component of granular alpha-synuclein pathology in the brainstem of Parkinson's disease.' 2008, 34, 272-283
Protein number see ncbi
Warnings This product is intended FOR RESEARCH USE ONLY, and FOR TESTS IN VITRO, not for use in diagnostic or therapeutic procedures involving humans or animals. This datasheet is as accurate as reasonably achievable, but Nordic-MUbio accepts no liability for any inaccuracies or omissions in this information.
About Rabbits are used for polyclonal antibody production by nordc. Rabbit antibodies are very stable and can be stored for several days at room temperature. nordc adds sodium azide and glycerol to enhance the stability of the rabbit polyclonal antibodies. Anti-human, anti mouse antibodies to highly immunogenic selected peptide sequences are" monoclonal like" since the epitope to which they are directed is less than 35 amino acids long.