Long description Glypican-3 encodes a putative extracellular proteoglycan that is inferred to play an important role in growth control in embryonic mesodermal tissues in which it is selectively expressed. It appears to form a complex with insulin-like growth factor and hence modulate IGF2 action. Glypican-3 is the human homolog of OCI-5, a GPI-linked proteoglycan first isolated from rat intestine. Originally identified as the molecular basis for Simpson-Golabi-Behmel syndrome (SGBS) also called Simpson dysmorphia syndrome (SDYS).
Antibody come from Synthetic peptide derived from the human NOL4 protein
Other description Provided as solution in phosphate buffered saline with 0.08% sodium azide. Total IgG
Antigen-antibody binding interaction Sheep anti Glypican-3 (GPC3) Antibody
Antibody is raised in Sheep
Antibody's reacts with Human
Antibody's reacts with these species This antibody doesn't cross react with other species
Antibody's specificity No Data Available
Application IHC (paraffin), WB
Antibody's suited for Antibody can be used for Western blotting (1-5 µg/ml) and immunohistochemistry on paraffin embedded tissues (10 µg/ml). Optimal concentration should be evaluated by serial dilutions.
Relevant references 1. Ueki, N., et al. 'NOLP: identification of a novel human nucleolar protein and determination of sequence requirements for its nucleolar localization.' Biochem Biophys Res Commun 1998;252:97-102._x000B__x000B_2. Wang, S.S., et al. 'Identification of novel methylation markers in cervical cancer using restriction landmark genomic scanning.' Cancer Res 2008;68:2489-2497._x000B__x000B_3. Visintin R, et al. 'The nucleolus: the magician's hat for cell cycle tricks.' Curr Opin Cell Biol 2000;12:372Ð7._x000B__x000B_4. Olson MO, et al. 'The nucleolus: an old factory with unexpected capabilities.' Trends Cell Biol 2000;10:189Ð96.
Protein number see ncbi
Warnings This product is intended FOR RESEARCH USE ONLY, and FOR TESTS IN VITRO, not for use in diagnostic or therapeutic procedures involving humans or animals. This datasheet is as accurate as reasonably achievable, but Nordic-MUbio accepts no liability for any inaccuracies or omissions in this information.