Long description Inhibits the synthesis of a number of cytokines, including IFN-gamma, IL-2, IL-3, TNF and GM-CSF produced by activated macrophages and by helper T-cells.Defects in IL10 are a cause of susceptibility to Crohn disease (CD) [MIM:266600]. CD is a form of remitting inflammatory bowel disease (IBD). CD may involve any part of the gastrointestinal tract, but most frequently the terminal ileum and colon. Bowel inflammation is transmural and discontinuous. Crohn disease is commonly classified as autoimmune disease.
Antibody come from Synthetic peptide derived from the human SUMO-1 protein.
Other description Provided as solution in phosphate buffered saline with 0.08% sodium azide. Protein A/G Chromatography
Antigen-antibody binding interaction Mouse anti Interleukin 10 (IL-10) Antibody
Antibody is raised in Mouse
Antibody's reacts with Human
Antibody's reacts with these species This antibody doesn't cross react with other species
Antibody's specificity No Data Available
Antibody's suited for Antibody can be used for Western blotting (1-5 µg/ml). Optimal concentration should be evaluated by serial dilutions.
Relevant references 1. Saitoh, H., et al. 'SUMO-1: wrestling with a new ubiquitin-related modifier.' Trends Biochem Sci 1997; 22(10):374-376_x000B__x000B_2. Muller, S., et al. 'Conjugation with the ubiquitin-related modifier SUMO-1 regulated the partitioning of PML within the nucleus.' EMBO J 1998; 17(1):61-70_x000B__x000B_3. Navascues J., et al. 'SUMO-1 transiently localizes to Cajal bodies in mammalian neurons.' J Struct Biol 2008; 163(2):137-146.
Protein number see ncbi
Warnings This product is intended FOR RESEARCH USE ONLY, and FOR TESTS IN VITRO, not for use in diagnostic or therapeutic procedures involving humans or animals. This datasheet is as accurate as reasonably achievable, but Nordic-MUbio accepts no liability for any inaccuracies or omissions in this information.
Test Mouse or mice from the Mus musculus species are used for production of mouse monoclonal antibodies or mabs and as research model for humans in your lab. Mouse are mature after 40 days for females and 55 days for males. The female mice are pregnant only 20 days and can give birth to 10 litters of 6-8 mice a year. Transgenic, knock-out, congenic and inbread strains are known for C57BL/6, A/J, BALB/c, SCID while the CD-1 is outbred as strain.