Degenerative Spermatocyte Homolog 2 - Blocking Peptide

  • Catalog name: X2358B
  • Supplier name: nordc
  • Size: 50 μg
  • Price: 168.00€
  • Category Proteins & Peptides
  • Long description Bifunctional enzyme which acts as both a sphingolipid delta(4)-desaturase and a sphingolipid C4-hydroxylase. Up-regulated during keratinocyte differentiation. Not expressed at day 0 or day 3 after differentiation, detected on day 6 and increases by day 9. Belongs to the fatty acid desaturase family. DEGS subfamily. Highly expressed in skin, intestine and kidney.
  • Antibody come from peptide
  • Other description Provided as solution in phosphate buffered saline with 0.08% sodium azide.
  • Clone not specified
  • Antigen-antibody binding interaction Degenerative Spermatocyte Homolog 2 - Blocking Peptide
  • Antibody is raised in Rabbit
  • Antibody's reacts with Human
  • Antibody's reacts with these species This antibody doesn't cross react with other species
  • Antibody's specificity No Data Available
  • Application Western blot
  • Antibody's suited for For use with SET polyclonal antibodies (Cat. No. X2088P & X2332P).
  • Storage -80ºC
  • Relevant references [1] von Lindern M., van Baal S., Wiegant J., Raap A., Hagemeijer A., Grosveld G.;_x000B_ Can, a putative oncogene associated with myeloid leukemogenesis, may be activated by fusion of its 3' half to different genes: characterization of the set gene.;_x000B_Mol. Cell. Biol. 12:3346-3355(1992)._x000B_[2] von Lindern M., van Baal S., Wiegant J., Raap A., Hagemeijer A., Grosveld G.;_x000B_Can, a putative oncogene associated with myeloid leukemogenesis, may be activated by fusion of its 3' half to different genes: characterization of the set gene.;_x000B_Mol. Cell. Biol. 12:3346-3355(1992)._x000B_[3] Vaesen M., Barnikol-Watanabe S., Goetz H., Adil Awni L., Cole T., Zimmermann B., Kratzin H.D., Hilschmann N.;_x000B_Purification and characterization of two putative HLA class II associated proteins: PHAPI and PHAPII.;_x000B_Biol. Chem. Hoppe-Seyler 375:113-126(1994)._x000B_[4] Nagata K., Kawase H., Handa H., Yano K., Yamasaki M., Ishimi Y., Okuda A., Kikuchi A., Matsumoto K.;_x000B_Replication factor encoded by a putative oncogene, set, associated with myeloid leukemogenesis.;_x000B_Proc. Natl. Acad. Sci. U.S.A. 92:4279-4283(1995)._x000B_[5] Li M., Makkinje A., Damuni Z.;_x000B_The myeloid leukemia-associated protein SET is a potent inhibitor of protein phosphatase 2A.;_x000B_J. Biol. Chem. 271:11059-11062(1996)._x000B_[6] Tsujio I., Zaidi T., Xu J., Kotula L., Grundke-Iqbal I., Iqbal K.;_x000B_Inhibitors of protein phosphatase-2A from human brain: structures, immunocytological localization and activities towards dephosphorylation of the Alzheimer type hyperphosphorylated Tau.;_x000B_Submitted (JUL-2003) to the EMBL/GenBank/DDBJ databases._x000B_[7] The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).;_x000B_Genome Res. 14:2121-2127(2004)._x000B_[8] Adachi Y., Pavlaki G.N., Copeland T.D.;_x000B_Identification and characterization of SET, a nuclear phosphoprotein encoded by the translocation break point in acute undifferentiated leukemia.;_x000B_J. Biol. Chem. 269:2258-2262(1994)._x000B_[9] Wang L.C., Chen Y.;_x000B_A relative factor in human rectum carcinoma.;_x000B_Submitted (APR-2007) to the EMBL/GenBank/DDBJ databases._x000B_[10] Carlson S.G., Eng E., Kim E.-G., Perlman E.J., Copeland T.D., Ballermann B.J.;_x000B_Expression of SET, an inhibitor of protein phosphatase 2A, in renal development and Wilms' tumor.;_x000B_J. Am. Soc. Nephrol. 9:1873-1880(1998)._x000B_[11] Seo S.-B., McNamara P., Heo S., Turner A., Lane W.S., Chakravarti D.;_x000B_Regulation of histone acetylation and transcription by INHAT, a human cellular complex containing the Set oncoprotein.;_x000B_Cell 104:119-130(2001)._x000B_[12] Minakuchi M., Kakazu N., Gorrin-Rivas M.J., Abe T., Copeland T.D., Ueda K., Adachi Y.; Identification and characterization of SEB, a novel protein that binds to the acute undifferentiated leukemia-associated protein SET.;_x000B_Eur. J. Biochem. 268:1340-1351(2001)._x000B_[13] Fan Z., Beresford P.J., Zhang D., Lieberman J.;_x000B_HMG2 interacts with the nucleosome assembly protein SET and is a target of the cytotoxic T-lymphocyte protease granzyme A.;_x000B_Mol. Cell. Biol. 22:2810-2820(2002)._x000B_[14] Fan Z., Beresford P.J., Oh D.Y., Zhang D., Lieberman J.;_x000B_Tumor suppressor NM23-H1 is a granzyme A-activated DNase during CTL-mediated apoptosis, and the nucleosome assembly protein SET is its inhibitor.;_x000B_Cell 112:659-672(2003)._x000B_[15] Fan Z., Beresford P.J., Oh D.Y., Zhang D., Lieberman J.;_x000B_Cell 115:241-241(2003)._x000B_[16] Olsen J.V., Blagoev B., Gnad F., Macek B., Kumar C., Mortensen P., Mann M.;_x000B_Global, in vivo, and site-specific phosphorylation dynamics in signaling networks.;_x000B_Cell 127:635-648(2006)._x000B_[17] Sprung R., Chen Y., Xu Y., Ball H., Pei J., Cheng T., Kho Y., Xiao H., Xiao L., Grishin N.V., White M., Yang X.-J., Zhao Y.;_x000B_Substrate and functional diversity of lysine acetylation revealed by a proteomics survey.;_x000B_Mol. Cell 23:607-618(2006)._x000B_[18] Molina H., Horn D.M., Tang N., Mathivanan S., Pandey A.;_x000B_Global proteomic profiling of phosphopeptides using electron transfer dissociation tandem mass spectrometry.;_x000B_Proc. Natl. Acad. Sci. U.S.A. 104:2199-2204(2007).
  • Protein number see ncbi
  • Warnings This product is intended FOR RESEARCH USE ONLY, and FOR TESTS IN VITRO, not for use in diagnostic or therapeutic procedures involving humans or animals. This datasheet is as accurate as reasonably achievable, but Nordic-MUbio accepts no liability for any inaccuracies or omissions in this information.
  • Test You can block the antibody by the specific target amino acid sequence of peptide.
  • Properties blocking peptide