Long description Longevity assurance genes (LAGs) represent a subgroup of the homeobox gene family. Five mammalian homologs have been reported, and the corresponding proteins have previously been investigated with respect to their key role in ceramide synthesis. However, members of the LAG family have been shown to be involved in cell growth regulation and cancer differentiation. May be involved in sphingolipid synthesis or its regulation. Interacts with ATP6V0C, ASGR1, ASGR2 and SLC22A1/OCT1. Localized to nuclear membrane a multi-pass membrane protein, may be expressed on endoplasmic reticulum membrane. Glycosylation on Asn-18 is not necessary for function. Like other LAG family members, the LASS6 protein contained a homeodomain and LAG1 domain. Lass6 displays highest homology to LASS5. The corresponding gene was localized to human chromosome 2q24.3, spanning a rather large genomic region of 318 kb. Sequences in mouse and zebrafish suggested a conservation of LASS6 in vertebrates because the protein and corresponding genomic sequences are highly conserved. LASS6 was shown to be broadly expressed in a wide range of tissues. Recent data suggested a role in cancer differentiation and early embryonic development.
Antibody come from Hybridoma produced by the fusion of splenocytes from mice immunized with recombinant PI-6 produced in E.coli and mouse myeloma cells.
Other description Provided as solution in phosphate buffered saline with 0.05% sodium azide. Antigen Immunoaffiinity Purification
Antigen-antibody binding interaction Rabbit anti Lass6 Antibody
Antibody is raised in Rabbit
Antibody's reacts with Human
Antibody's reacts with these species This antibody doesn't cross react with other species
Antibody's specificity No Data Available
Application Western blot
Antibody's suited for Antibody can be used for Indirect immunofluorescence, immunoprecipitation, ELISA and flow cytometry. Optimal concentration should be evaluated by serial dilutions.
Relevant references 1. Scott FL, Paddle-Ledinek JE, Cerruti L, Coughlin PB, Salem HH and Bird PI (1998). Proteinase inhibitor 6 (PI-6) expression in human skin: induction of PI-6 and a PI-6 / proteinase complex during keratinocyte differentiation. Exp. Cell Res. 245, 263-271._x000B__x000B_2. Scott FL, Hirst CE, Sun J, Bird CH, Bottomley SP, Bird PI (1999). The Intracellular Serpin Protease Inhibitor 6 Is Expressed in Monocytes and Granulocytes and Is a Potent Inhibitor of the Azurophilic Granule Protease, Cathespin G. Blood, Vol 93. No 6 (March 15), 1999; pp 2089-2097._x000B_
Protein number see ncbi
Warnings This product is intended FOR RESEARCH USE ONLY, and FOR TESTS IN VITRO, not for use in diagnostic or therapeutic procedures involving humans or animals. This datasheet is as accurate as reasonably achievable, but Nordic-MUbio accepts no liability for any inaccuracies or omissions in this information.
About Rabbits are used for polyclonal antibody production by nordc. Rabbit antibodies are very stable and can be stored for several days at room temperature. nordc adds sodium azide and glycerol to enhance the stability of the rabbit polyclonal antibodies. Anti-human, anti mouse antibodies to highly immunogenic selected peptide sequences are" monoclonal like" since the epitope to which they are directed is less than 35 amino acids long.