Long description LASS3 (Longevity Assurance homolog 3) is a member of a highly conserved family of proteins from yeast to humans which are involved in the synthesis of ceramide. Overproduction of LASS3 appears to results in increases in several ceramide species, with some preference toward those having middle to long chain fatty acid acyl-CoAs. Also appears to have (dihydro)ceramide synthesis activity. LASS3 expression appears to be limited almost solely to the testis.
Antibody come from Synthetic peptide derived from the human Lass1 protein.
Other description Provided as solution in phosphate buffered saline with 0.08% sodium azide.
Antibody's reacts with these species This antibody doesn't cross react with other species
Antibody's specificity No Data Available
Application Western Blot
Antibody's suited for Antibody can be used for Western blotting (1:400 starting dilution). Other uses not yet tested. Only reacts with human Lass1 protein. Also cross reacts with human GDF1. Optimal concentration should be evaluated by serial dilutions.
Relevant references  Lee S.-J.; Expression of growth/differentiation factor 1 in the nervous system: conservation of a bicistronic structure.; Proc. Natl. Acad. Sci. U.S.A. 88:4250-4254(1991)._x000B__x000B_ Jiang J.C., Kirchman P.A., Zagulski M., Hunt J., Jazwinski S.M.; Homologs of the yeast longevity gene LAG1 in Caenorhabditis elegans and human.; Genome Res. 8:1259-1272(1998)._x000B__x000B_ Grimwood J., et al.; The DNA sequence and biology of human chromosome 19.;_x000B_Nature 428:529-535(2004)._x000B__x000B_ The MGC Project Team; The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).; Genome Res. 14:2121-2127(2004).
Protein number see ncbi
Warnings This product is intended FOR RESEARCH USE ONLY, and FOR TESTS IN VITRO, not for use in diagnostic or therapeutic procedures involving humans or animals. This datasheet is as accurate as reasonably achievable, but Nordic-MUbio accepts no liability for any inaccuracies or omissions in this information.
Test You can block the antibody by the specific target amino acid sequence of peptide.