(S)-Isopropyl 2-(((R)-(((2R,3R,4R,5R)-3-((tert-Butyldimethylsilyl)oxy)-5-(2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)-4-fluoro-4-methyltetrahydrofuran-2-yl)methoxy)(phenoxy)phosphoryl)amino)propanoate

  • Catalog name: I872830
  • Supplier name: trca
  • Size: 2,5 mg
  • Price: 268.00€
  • Check this product
  • Chemical available in other sizes Please inquire size and price
  • Stock availability Pending QC
  • Cas number This product doesn't have CAS Number
  • Chemical's molecular weight 643.71
  • Chemical's main applications (S)-Isopropyl 2-(((R)-(((2R,3R,4R,5R)-3-((tert-Butyldimethylsilyl)oxy)-5-(2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)-4-fluoro-4-methyltetrahydrofuran-2-yl)methoxy)(phenoxy)phosphoryl)amino)propanoate is an intermediate in the synthesis of Sofosbuvir (R)-Phosphate (S675615), which is an impurity of PSI-7977 (P839640), a prodrug that is metabolized to the active antiviral agent 2'-deoxy-2'-α-fluoro-β-C-methyluridine-5'-monophosphate and is currently being investigated in phase 3 clinical trials for the treatment of hepatitis C. Studies have profiled PSI-7977 as a nucleotide inhibitor of hepatitis C virus, exerting selective inhibitory effects towards HCV NS5B polymerase.
  • Chemical's formula C28H43FN3O9PSi
  • Physical properties White Solid
  • Melting temperature No Data Available
  • Boiling temperature No Data Available
  • Chemical's soluble in Chloroform, Dichloromethane, Methanol
  • Stability conditions No Data Available
  • Storage No Data Available