NCF1/p47 phox(Ser359) Antibody, ALEXA FLUOR 488

  • Catalog name: bs-11445R-A488
  • Supplier name: Bioss Primary Conjugated Antibodies. ALEXA FLUOR
  • Size: 100ul
  • Price: 350.15€
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  • Long name NCF1/p47 phox(Ser359) Antibody, ALEXA FLUOR 488 Conjugated
  • Also known as Anti-NCF1/p47 phox Ser359 PAb ALEXA FLUOR 488
  • Category Conjugated Primary Antibodies
  • Conjugated with ALEXA FLUOR® 488
  • Host Organism Rabbit (Oryctolagus cuniculus)
  • Target Antigen NCF1/p47 phox Ser359
  • Specificity This is a highly specific antibody against NCF1/p47 phox Ser359.
  • Modification Phosphorylation
  • Modification Site Ser359
  • Clonality Polyclonal
  • Clone Polyclonal antibody
  • Concentration 1ug per 1ul
  • Source KLH conjugated synthetic phosphopeptide derived from human NCF1 around the phosphorylation site of Ser359
  • Gene ID Number 653361
  • Tested applications IF(IHC-P)
  • Recommended dilutions IF(IHC-P)(1:50-200)
  • Crossreactivity Human, Rat
  • Cross-reactive species details Due to limited amount of testing and knowledge, not every possible cross-reactivity is known.
  • Background of the antigen The heredity chronic granulomatous disease (CGF) has been linked to mutations in p47-phox and p67-phox. The cytosolic proteins p47-phox and p67-phox, also designated neutrophil cytosol factor (NCF)1 and NCF2, respectively, are required for activation of the superoxide-producing NADPH oxidase in neutrophils and other phagocytic cells. During activation of the NADPH oxidase, p47-phox and p67-phox migrate to the plasma membrane where they associate with cytochrome b558 and the small G protein Rac to form the functional enzyme complex. Both p47-phox and p67-phox contain two Src homology 3 (SH3) domains. The C-terminal SH3 domain of p67-phox has been shown to interact with the proline-rich domain of p47-phox, suggesting that p47-phox may faciliate the transport of p67-phox to the membrane.
  • Purification Purified by Protein A.
  • Storage conditions Store this antibody in aqueous buffered solution containing 1% BSA, 50% glycerol and 0.09% sodium azide. Keep refrigerated at 2 to 8 degrees Celcius for up to one year.
  • Excitation emission 499nm/519nm
  • Synonyms NCF1Ser359; p47 phoxSer359; NCF1 phospho S359; 47 kDa autosomal chronic granulomatous disease protein; 47 kDa neutrophil oxidase factor; NADPH oxidase organizer 2; NCF 47K; Neutrophil cytosol factor 1; Neutrophil cytosolic factor 1; Neutrophil NADPH oxidase factor 1; Nox organizer 2; Nox organizing protein 2; NOXO2; p47 phox; p47phox; ;SH3 and PX domain containing protein 1A; SH3PXD1A; NADPH oxidase p47 phox; NCF1_HUMAN.
  • Properties For facs or microscopy Alexa 1 conjugate.Alexa Fluor 488 has the same range to that of fluorescein isothiocyanate (FITC), yet the Anti-NCF1/p47 phox Ser359 has a very high photo stability. As a result of this photo stability, it has turned into an antibody for fluorescent microscopy and FACS FLOW cytometry. It is distinguished in the FL1 of a FACS-Calibur or FACScan. Also Alexa Fluor 488 is pH stable.If you buy Antibodies supplied by Bioss Primary Conjugated Antibodies. ALEXA FLUOR they should be stored frozen at - 24°C for long term storage and for short term at + 5°C.
  • Conjugation Alexa Fluor
  • French translation anticorps