Gene info Recently, a BH-3 only member of the Bcl-2 family have been identified in human and mouse and designated as Noxa (for damage). The expression of the Noxa gene involves direct activation of its promoter by p53. Increased expression of Noxa protein occurs in normal thymocytes but not in p53-deficient thymocytes. Noxa cDNA codes for a 103-amino acid protein. The coimmunoprecipitation data suggest that Noxa protein may interact with proteins belonging to the Bcl-2 family, such as, Bcl-XL and Mcl-1. Oda et al have also shown that blocking the endogenous Noxa induction results in the suppression of apoptosis. Treatment of cells with Noxa antisense oligonucleotides blocks radiation-induced apoptosis suggesting that Noxa may represent a mediator of p53-dependent apoptosis.
Gene names PMAIP1, NOXA, PMA-induced protein 1, Protein Noxa, APR
Antibodie's label unlabelled serum
Purity Protein G Column
Ab raised in Rabbit
Antigen PMAIP1 antibody was made against amino acids 51 - 66 and 75-90 of PMAIP1 (Mouse).
Immuno application Western Blot, immuno-histo-chemistry
Antibody advice PMAimmunoprecipitation1 antibody can be used in immunohistochemistry starting at 20 ug/mL, and flow cytometry.