Gene info
Recently, a BH-3 only member of the Bcl-2 family have been identified in human and mouse and designated as Noxa (for damage). The expression of the Noxa gene involves direct activation of its promoter by p53. Increased expression of Noxa protein occurs in normal thymocytes but not in p53-deficient thymocytes. Noxa cDNA codes for a 103-amino acid protein. The coimmunoprecipitation data suggest that Noxa protein may interact with proteins belonging to the Bcl-2 family, such as, Bcl-XL and Mcl-1. Oda et al have also shown that blocking the endogenous Noxa induction results in the suppression of apoptosis. Treatment of cells with Noxa antisense oligonucleotides blocks radiation-induced apoptosis suggesting that Noxa may represent a mediator of p53-dependent apoptosis.
Gene names
PMAIP1, NOXA, PMA-induced protein 1, Protein Noxa, APR
Antibodie's label
unlabelled serum
Purity
Protein G Column
Ab raised in
Rabbit
Type
Polyclonal
Immunoglobulin
IgG
Antigen
PMAIP1 antibody was made against amino acids 51 - 66 and 75-90 of PMAIP1 (Mouse).
Immuno application
Western Blot, immuno-histo-chemistry
Antibody advice
PMAimmunoprecipitation1 antibody can be used in immunohistochemistry starting at 20 ug/mL, and flow cytometry.
Keep at
PMAIP1 antibody should be stored long term (months) at -20 grades C and short term (weeks) at 4 grades C. As with all antibodies avoid freeze/thaw cycles.
Works with
Human, Mouse, Rat
Omim nr
6919841
Ncbi nr
Q13794
Vial with antibody
in solution
NCBI GENE nr
5366
GENE symbol
PMAIP1
Antigene name
phorbol-12-myristate-13-acetate-induced protein 1
Source
Homo sapiens
Protein nr
Q13794
Properties
If you buy Antibodies supplied by proscience they should be stored frozen at - 24°C for long term storage and for short term at + 5°C.