TOX Antibody: TOX (thymocyte selection-associated high mobility group (HMG) box protein) is a member of the HMG box family of DNA-binding proteins and likely plays a role in the regulation of T-cell development. It is a 526 amino acid nuclear protein and the expression of TOX is upregulated by pre-T cell receptor (pre-TCR) and TCR activation in immature thymocytes. TOX-mediated positive selection is associated with up-regulation of RUNX3 and is calcineurin dependent. TOX-dependent transition to the CD4+CD8 stage is required for development of class II major histocompatibility complex-specific T cells.
TOX Antibody: TOX1, KIAA0808, Thymocyte selection-associated high mobility group box protein TOX, Thymus high mobility group box protein TOX
TOX Antibody is affinity chromatography purified via peptide column.
Ab raised in
No alternatively spliced transcript variants have been observed.
TOX antibody was made against a 17 amino acid synthetic peptide near the amino terminus of human TOX.
ELISA, Western Blot, immuno fluorescence
TOX antibody can be used for detection of TOX by Western blot at 1 - 2 ug/mL. For immunofluorescence start at 20 ug/mL.
Suspention, pH, azide
TOX Antibody is supplied in PBS containing 0.02% sodium azide.
TOX antibody can be stored at 4 grades C for three months and -20 grades C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Vial with antibody
Quantity per ml
NCBI GENE nr
thymocyte selection-associated high mobility group box protein TOX
If you buy Antibodies supplied by proscience they should be stored frozen at - 24°C for long term storage and for short term at + 5°C.