NCF1/p47 phox(Ser359) Antibody, Cy3 Conjugated

  • Catalog name: bs-11445R-Cy3
  • Supplier name: Bioss Primary Conjugated Antibodies
  • Size: 0.1ml
  • Price: 368.00€
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  • Long name NCF1/p47 phox(Ser359) Antibody, Cy3 Conjugated
  • Category Conjugated Primary Antibodies
  • Conjugation Cy3
  • Host Organism Rabbit (Oryctolagus cuniculus)
  • Target Antigen NCF1/p47 phox Ser359
  • Specificity This is a highly specific antibody against NCF1/p47 phox Ser359.
  • Modification Phosphorylation
  • Modification site Ser359
  • Clonality Polyclonal
  • Clone Polyclonal antibody
  • Concentration 1ug per 1ul
  • Source KLH conjugated synthetic phosphopeptide derived from human NCF1 around the phosphorylation site of Ser359
  • Gene ID number 653361
  • Tested applications IF(IHC-P)
  • Recommended dilutions IF(IHC-P)(1:50-200)
  • Crossreactivity Human, Rat
  • Crossreactive species details Due to limited amount of testing and knowledge, not every possible cross-reactivity is known.
  • Antigen background The heredity chronic granulomatous disease (CGF) has been linked to mutations in p47-phox and p67-phox. The cytosolic proteins p47-phox and p67-phox, also designated neutrophil cytosol factor (NCF)1 and NCF2, respectively, are required for activation of the superoxide-producing NADPH oxidase in neutrophils and other phagocytic cells. During activation of the NADPH oxidase, p47-phox and p67-phox migrate to the plasma membrane where they associate with cytochrome b558 and the small G protein Rac to form the functional enzyme complex. Both p47-phox and p67-phox contain two Src homology 3 (SH3) domains. The C-terminal SH3 domain of p67-phox has been shown to interact with the proline-rich domain of p47-phox, suggesting that p47-phox may faciliate the transport of p67-phox to the membrane.
  • Purification method This antibody was purified via Protein A.
  • Storage conditions Keep the antibody in an aqueous buffered solution containing 1% BSA, 50% glycerol and 0.09% sodium azide. Store refrigerated at 2 to 8 degrees Celcius for up to 1 year.
  • Excitation Emission 512,550nm/570,615nm
  • Synonyms NCF1Ser359; p47 phoxSer359; NCF1 phospho S359; 47 kDa autosomal chronic granulomatous disease protein; 47 kDa neutrophil oxidase factor; NADPH oxidase organizer 2; NCF 47K; Neutrophil cytosol factor 1; Neutrophil cytosolic factor 1; Neutrophil NADPH oxidase factor 1; Nox organizer 2; Nox organizing protein 2; NOXO2; p47 phox; p47phox; ;SH3 and PX domain containing protein 1A; SH3PXD1A; NADPH oxidase p47 phox; NCF1_HUMAN.
  • Properties If you buy Antibodies supplied by Bioss Primary Conjugated Antibodies they should be stored frozen at - 24°C for long term storage and for short term at + 5°C.Cy3 antibodies are excited by the 488-nanometer wave of an argon laser and the 633-nanometer line of a helium-neon diode laser. 1 of the Anti-NCF1/p47 phox Ser359 can be used in flow cytometry but typically shows lower fluorescence intensity comparable to that of PE or APC. This Bioss Primary Conjugated Antibodies antibody is well suited for fluorescent microscopy.
  • Additional conjugation cy3 conjugation kit
  • French translation anticorps